- P5p anxiety reddit I recently lowered my b6 dose to 12. My estrogen and prolactin and test ratio is night and day with these supps. gov/10746516/ I recently went on benfo. On blast is where issues can arise. Some people have also mentioned on reddit and forums that they got toxicity from taking P5P but there's no way to verify those claims as 1. I’ve taken tons of supplements, pills, SSRI’s, SNRI’s. I know what a placebo effect is. Now you may respond very well to P5P and it ends up stimulating a lot of dopamine, this may work for some. I suggest sticking with 20 mg, or at least with 12-14 mg if you cannot take 20 mg. My ears turn red 3-4 hours after taking P5P, and this lasts for a few hours. I thought he recommended the simple form of B6 over the P5P form. From time to time I was also taking a B complex with P5P in it. i noticed i could laugh more easily, enjoy music and my sleep This subreddit provides advice and acts as a public database for new science and anecdotes concerning the use of these diets in mitigating conditions such as: Bipolar I(mania/depression), Bipolar II:(depressive, hypomanic), Depression, Schizophrenia, Mania, Anorexia, Addiction, Anxiety, PTSD, ADHD. What went wrong? Any reccomendation? The dose was 27 mg sublingual. I bought Solgar P5P 50 mg enteric coated tablets. The clinical studies which do show a significant impact to prolactin (and growth hormone) levels seem all to exclusively use B6. I want to try… Theres a bioactive form of vitamin b6 which lowers prolactin called P5P at doses of 20mg - 100mg (it doesnt carry the same risks as vitamin b6 pridoxine), but don't take this at the same time as vitamin b6 as you could get b6 overload. P5P is needed to synthesize these neurotransmitters. It's been suggested that p5p is less toxic than pyridoxine, but as it's the active form a much lower dose is required. Reference range looks like max 300. There's a peculiar condition called Mortons Foot which occurs if you cannot assimilate B6 properly. I have insomnia, numbness/weakness in my hands and I had vibrations which have now stopped. Supplements for anxiety/ocd. I deal with almost constant anxiety… I've struggled with a lot of issues like anxiety, depression, and other seemingly random problems since middle school, but I think my issue is actually reduced dopamine. I couldn't find how much of that 30mg was Zinc and how much Aspartate, so this confused me a bit. Heard vitb6/P5P helps. P5P increases GABA levels, which helps reduce anxiety. It's not dangerous in p5p form. I've had virtually no anxiety for six months prior. Now I have B6 toxicity. Think all those would be beneficial for you. If I get any neuropathy, I will stop and later revert to 20. but now even few days of taking choline is enough to anxiety comeback. Any toxic affects in the studies were at doses over 1000mg per day. Someone told me that it could actually mean deficiency seeing that result, but I always take a multivitamin with 6 in it. Use folinic acid, regular B6 not P5P, and the adeno and hydroxy forms of B12. P5P destroyed a lot of my anxiety and made me more confident and assertive, but it only worked properly when I was getting all the other B vitamins and vitamin A in beef liver, plus loads of magnesium which is needed for it to work. Underdosing carries its own risks, meaning that you will miss out on the benefits of B6 that come exclusively from better doses. Most B complexes won't have a high enough dose so I would buy it as a separate supplement. but after few months i got extreme anxiety. Basically, they exploit your ignorance of the subject and push their products. CBD has aided some with anxiety, and is relatively safe. If bacopa makes you tired, it might not be for you, although I doubt it judging by your post. Where they actually taking P5P 4. 5mg. 5mg P5P I notice almost no benefits or side effects, feels like fresh water, maybe a little bit of anxiety but not completely sure. That is Reddit in general. I do have some 5HTP so if those issues do really flare up I could add that I suppose. P5P is great for keeping it lower, but does near nothing once it's up. Most probably cheaper option i. My blood levels went up to 4X the upper limit from a b complex with 20mg daily for six weeks. B6 has a half life of roughlty 35 days, and some poor metabolizer can end up with a toxic buildup in the nerves, creating symptoms of peripheral neuropathy. I was all ready taking 100mg B-Complex. P5P is neurotoxic at that dosage, and you have a good chance of developing neuropathy if you continue supplementing. Which means, that there is no difference of taking B6 in the form of pyridoxine HCL or P5P. what i’ve done, to completely eliminate social anxiety was first fix my diet, second workout hard daily or as much as possible, get outside, quit masterbation, and talk to random people as much as I can. No P5P, and the enzymes that make the neurotransmitters don't work properly. Dec 20, 2014 · p5p post anxiety - posted in Supplements: 3 weeks ago I was taking sublingual p5p , b6 source, I was feeling good for the time. in my honest experience, you’re trying to hide from the problem by looking for a drug/supplement to fix the anxiety. Could I really be deficient still? This subreddit is for questions and discussion related to testosterone replacement therapy and testosterone. There are some sensitive that it can happen at much lower doses but nd is still a lower dose then that. Afaik, no one in this world is documented to have had adverse effects from 20 mg of P5P, assuming that was the only B6 they took. This then doesn't really mean that P5P is going to be stimulating, it will simply help support neurotransmitter synthesize. r/Ketoscience r/Keto4 p-5-p is safer but can still cause problems. nlm. I just started taking 200 mg P5P three days ago to deal with very high prolactin and I had anxiety/panic episodes back to back days now so I am stopping. It will take a few months of use before I can comment on 40 mg of P5P. It is unclear whether it is safe or not. I just stopped a week ago. I already do a lot of things for anxiety so hopefully it doesn’t get affected too much. For simplicity and budget sake, your best option would be P5P, but if you want a more comprehensive overall effect, then I would suggest going for Infini-B. Here’s what you need to know: Recommended dosage: The optimal dosage of P5P for anxiety management can vary depending on individual factors. Most do not respond well enough for it to be an effective treatment. I'm homozygous for C677T. Experiences wanted. P5P is the way to do it, from what I understand. (If pyridoxine levels are actually a lot higher than the measured P5P it can take months to normalize) Symptoms usually worsen during 2-6 weeks after stopping before starting to improve. I've been taking P5P b6 almost 4 years at 25mg per day, everyday. I have bad anxiety and brain fog in general as of recent. Maybe that would help some. Alcohol. Why the strong reaction to b6? 22 votes, 22 comments. what blood test can proof this? i used to take various choline sources because of my bad liver tests and this helps me. -anxiety/depression slightly better -sleep improvement is hit or miss because sometimes i get insomnia sometimes i feel well rested (im presuming it depends on the time i take p5p) -holding less water -feel more joyful/music sounds better/feel joy from simple things again -more energy P5P plays arguably the most important role in dopamine synthesis, but the other B-vitamins also have a role in dopamine synthesis and metabolism. my joints feel like butter on NPP - heavy leg movements, pressing, etc. So far I've tried it two times: -1st time : Just a quarter of tablet on an empty stomach (very hard to break by the way) + 22 mg Zinc Picolinate. But maybe he revised that unbeknownst to me. and ive read this can have something to do with It says mixture of both p5p and pyridoxine HCl. 50mg P5P, 400IU Vit E P5P (activated vitamin b6 that can help reduce prolactin a lot) CABERGOLINE (perscription drug that is way stronger than p5p that you can buy via express PCT) Those are my 2 recommendations. perhaps mood a bit better and appetite? Posted by u/Puzzleheaded_Box_685 - No votes and 2 comments Since I also suffer from anxiety, heart palpitations, poor sleep, nervousness, etc, I am interested in lowering my prolactin to normal / optimal levels. This past month, I was taking 50mg P5P a day. The first few days I was riding a nice emotional and energy high but by the third day of it I had developed persistent anxiety, occasional un-provoked panic attacks, diarrhea, and nausea. P5p being the active version can be easily cleared by the body. Interestingly, I can find no clinical research comparing the benefits of P5P to B6. I checked out my gf while shopping last week and boom spontaneous erection at the store 🤣. Posted by u/Puzzleheaded_Box_685 - No votes and 2 comments Then when you take a high dose of B12 (I take 1,000 mcg), the body puts it to work and tries to make more red blood cells rapidly, which depletes its stores of potassium, resulting in hypokalemia and its symptoms, which can include insomnia, anxiety, and twitching. P5p was huge for me. I have high prolactin from hormone use. Taking P5P 50mg per day to combat prolactin Taking Berberine 500mg before meals that could spike blood sugar Following a healthy low glycemic index (GI) diet on "on" days Consuming a shot of diluted apple cider vinegar before meals Blood glucose monitor for measuring fasted blood glucose Other unrelated supplements that could help: facing the fear head on. You dont have to Google much before you find many people who claim to be b6 toxic from p5p. I've tried different forms of methyl-b12, methylfolate, and P5P. If you have been deficient for some time, you will surely keep improving. Whenever I try to stop taking p5p I get anxiety. Took about a gram the first day in three doses. Will supplement with mk7 and p5p 200mg, always have caber on hand but have never had to use it. i think 200mg p5p is a the best amount to lower it, from my own experience. Fibromyalgia pain the same. There are plenty of other issues that can occur from this deficiency that can only be remedied through P5P supplementation. I dont understand why more people aren't aware of the dangers of B6, almost everyone on this sub take such massive doses of it. I remember discarding all my P5P form after hearing Ray's thoughts. You name it I’ve been on it for mood disorders and anxiety. That effect has been shown in studies. So lately I've been playing around with taking l-tryptophan (4-5 doses of 500mg a day) along with L-tyrosine (3 doses of 500mg daily) and taking them along with a complete vitamin b complex with boosted p5p to help their conversion and fucking god do I feel great. Went to an excessive number of doctors that told me I had anxiety since every test possible came back normal. Im on 150 mg t with 500/1000 iu HCG / W p5p and e shoot up my libido Like a rockef since i had mid higher prolactin it works very well . My body was rigid and shakey and I could feel the adrenaline pumping and it wouldn’t let up. Thanks in advance. (I was also taking 750iu HCG weekly, 5mg Cialis daily, and 300mg P5P daily) Benefits: noticed more fullness and increased pump within 7-10 days of beginning the cycle. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. Does anyone know if these side effects can be mitigated with other supplements? Some people don't absorb the pyridoxine form at all. Taking high-dose Vitamin B6 tablets has been shown to reduce feelings of anxiety and depression. Our body converts pyridoxine HCl to p5p to be used. There are some minor ups and downs but I feel pretty dialed in. true. My B-complex had pyridoxine and I was taking P5P at 50mg dosage first then 100mg. Some of these are helped by high dose B1, and some were improved with iron status improvements, but the neuropathies, cold/hands and feet, brain fog/fatigue, breathing and anxiety were all exacerbated greatly upon resumption of the P5P. It's an anecdote 2. Dialed in meaning good energy level, decent libido, minimal anxiety. maybe try glycine for the insomnia. It's the active form of B6. If taking p5p is increasing dht the the hair loss is expected to happen, meanwhile when dht is high you feel happy and content. Symptoms included: brain fog, heart pounding 24/7, chest pain, exercise intolerance, nausea, gi irregularity, fatigue, anxiety flair ups, trouble focusing, sleep issues, muscle twitching, headaches. The original ZMA actually contained Zinc Monomethionine Aspartate in 30mg, Magnesium Aspartate in 450mg, and Pyridoxine in 10. op my prolactin was at 1000, 2 cycles of p5p got my prolactin down to 200, it works well. 200mg may result in negative symptoms. I made some research and I found that there was another B6 formula available (P5P). Seems to be p5p turn isn't supposed to do it at all according to this article and it only happens at much higher doses. Jun 30, 2020 · Sunlight, magnesium, ashwaghanda, enough protein, good fat consumption. I stopped b6 about 2 months ago my symptoms were heart palpitations, full body tremors, IBS, dizziness, extreme anxiety, depression, muscle weakness, frequent urination, POTS, erratic blood pressure, Depersonalization, brain fog insomnia and compromised vision. ncbi. Agreed that P5P is not an effective intervention for elevated prolactin. . It doesn’t work as well for mood, but it’s good enough. but all of a sudden I woke up with a feeling of anxiety, and it lasts for 5 days all day long, more or less. I am now however retrying taking it twice daily, so a total of 40 mg of P5P per day, together with 0 mg of pyridoxine. Jul 29, 2024 · How to Use P5P for Anxiety Relief. ) The main effect that's noticeable from large doses of P5P, is more intense and memorable dreams. Edit: Prolactin 468 mU/L after TRT, 360 pre-TRT. The lack of fatigue lasted three days, then other symptoms have gotten worse as predicted. I have alprazolam I take every night and finally took a dose at 830 to which I had no improvement and I usually do. After a week I've felt way more sharp, anxiety which was getting really bad suddenly dropped very low - I've even noticed I'm more confident and assertive, and only taurine has ever had that effect, and nothing like this. As I understand, 20 mg of P5P per day is safe. Well, that or a medicine called 'Cabergoline' which seems a bit excessive to start with IMO. Young adults taking high-doses of the vitamin reported feeling less anxious and depressed after taking the supplements every day for a month. All in all it seems that extremally high doses of P5P can produce breakdown products that can do damage themselves. Still, the concentration van get high and you can get tingles, but it's easily filtered out by any diuretic, eg. I got brain fog anxiety and a rash on my face and chest from it. They probably just added tiny bit p5p and printed over label as mixture to avoid law suit. I then switched to 1:1 tryptophan:tyrosine ratio which fixed things. But since I had the jitters also with the methyl shots, I suspect methylfolate probably causes the anxiety. It also focuses on lifestyle activities like exercise and nutrition for raising testosterone levels naturally or anything else related to testosterone the substance. Yeah I’ve heard about that. Posted few various groups, and already started P5P[ active B6] to great success . If you have not had your other gene variants tested, which I would highly recommend, do not take any methylated vitamins or P5P as they can be over stimulating and cause anxiety. I saw two separate studies concluding that B6 can reduce prolactin by around 40% on average. I actually just finished a bottle of 50mg P5P to help with prolactin, and didn't notice much of anything. I tried taking 200 mg P5P for only a few days to help lower my prolactin while I wait to get pituitary imaging done. They need the active form which is P5P. If you’re considering using P5P for anxiety relief, it’s crucial to approach it with a well-informed strategy. They went away after couple days of not taking p5p. 5mg, half of the dosage I was taking. Worth a shot if anyone is in the same situation. Same . You can still grow gyno while being on ralox if it is prolactin induced. Pyridoxine is the form of B6 that has known danger of peripheral nerve damage. I take 20mg of p5p a day and 20mg of inactive b6 (form multivitamin)? Should I stop taking them? Should I just stop the inactive and keep up the p5p. P-5-P gave me panic attacks and anxiety after a few days. 13 votes, 14 comments. Extreme anxiety (no prior history of anxiety) - I could not leave the house for 10 days The best forms of vitamin B6 are listed as P5P, pyridoxal-5-phosphate, or I started to develop random muscle twitches after couple weeks of supplementing 50mg p5p (active b6). Do a reduced or max 100% RDA B6 diet use Chronometer App. I would be cautious with B6, and be sure to take the active form called p5p. Note that the RDA is 2mg/day. I am celiac, I know I have a b6 deficiency and some other tests showed I am high in urine serine which is also a marker of low b6. But it takes around a month to get out of your system 31-35 days, one thing pyroxidal phosphate does is shuttle magnesium into the cells it also needs zinc to aid in its transport and utilisation. Try at your own risk! But after finding the right dose for me (for reference purposes, mine is kinda low, 250 mcg of 5-MTHF + 5mcg methylB12 + 10mg P5P daily, no more than that), after ~3 months, the hand and leg tingling was gone. Labs only measure P5P so no real way to know pyridoxine levels. It could be a nocebo effect 3. Cabergoline will drop it like a rock, but if you're taking pharma that's causing it, waste of time. Reply reply HanMegistus I used 50 mg of the P5P version and it's just had this crazy waking up feeling on my body and brain. It is typically mild at best. However, the MTHFR "gurus" on their blogs and YouTube had you believe that P5P is a better form as it is "the active form". Don't forget to supplement magnesium. I also use dim . Tribulus , maca , p5p , e 400 , cal-mg-zinc are my everyday stuff . Since the pandemic Reddit has gone to shit. From novel/alternative substances, to established medications. p5p. I used 50 mg of the P5P version and it's just had this crazy waking up feeling on my body and brain. It does indeed seem to minorly regulate cortisol too. I also have histamine issues and I feel like they get worse when I try to get off p5p. There are definitely some people who are sensitive to it. If I take 4. Will reduce the prolactin spike. P5P active form of vitamin B6 does increase dopamine and also lowers prolactin levels I've done it a lot. Slow COMT is likely to react negatively to the P5P form of B6. I see a sexy girl and I feel horny. it got better after i stop taking choline, anxiety gone away. P-5-P has a half life of 31. Get the Reddit app Scan this QR code to download the app now. I will add more later when I can get on my laptop. In my mind, you want to work toward optimising BH4 metabolism, P5P metabolism, as well as methylation to get the best results for neurotransmitter synthesis. Do all of this and reduce your B6 to 10 mg, the prolactine-lowering effect isn't strong and B6 toxicity is well described; the betterment of your general health will reduce your prolactine potently, the iodine will normalize thyroid output which normalizes heightened PRL; safe experimentation can be had with RRR alpha tocopherol at around 400mg/d on top of this stack. Raloxifene is blocking estrogen receptors, not prolactin. For research, treatments, and personal stories regarding Chronic Fatigue Syndrome (CFS)/Myalgic Encephalomyelitis (ME). pyridoxine HCl is more. It made me feel very good for the first few weeks but then all it does now is make me nauseous so I guess I can't take it anymore. Review I'm a 25M and I recently did bloodwork which showed very high prolactin (45 ng/mL, this is about 3x higher than the male reference range). I am currently taking a high dose of B6 to reduce prolactin levels. I started taking P5P for prolactin issues I’ve been experiencing from Finasteride/mk677 and it seems to have fixed those issues but also helped immensely with my brain fog, energy, problems with ADHD, libido up, social anxiety/awkwardness significantly reduced. The official subreddit community for the Youtube channel More Plates More Dates. If you have anxiety, it's worth at least trying P5P to see if you get any improvement. I took the B-complex for 16 months and the P5P around 6 months. Against Anxiety And Cognitive 3 days into P5P and Vit E I have erections like a 14 year old again. The feeling of anxiety and depression should be A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study (significantly reduced PMS symptoms, including mood swings, irritability and anxiety) - https://pubmed. I suspect this because: Lack of motivation and stimulation, even for my hobbies Excessive fatigue, tiredness, and apathy (feels like depression symptoms) 87 votes, 34 comments. Proper nutrition and going out in the sun is the answer for most though Jan 21, 2020 · Opinion is catching up with Ray Peat who recommended keeping any B6 dose down to about 10mg. Low zinc is also associated with anxiety. Definitely see what the doc wants to do. Just be careful and if you notice any twitching or cramps lower the dose to 25mg 179K subscribers in the moreplatesmoredates community. Have ran all sorts of dosages between 100mg-600mg Prefer it between 250-375 My favorite stack: 375 test, 375 nand, 450 eq Final answer: Nand is easily my favorite compound Monday night, popped 50mg of p5p 50 and 61IU of mixed tocopherol vitamin E and… wow the effects hit HARD yesterday morning. I don’t tell this to anyone because no one believes me and it’s so specific to the individual but taking p5p helped my mood, confidence, and social anxiety tremendously. Seem to require less sleep and am more emotionally stable and stoic than usual. e. I've never heard of P5P specifically to help with anxiety or energy. I will try to answer anyway. I've been taking 300mg of p5p per day for 2 weeks and my libido is up and have no side effects. i started noticing a difference almost immediately the first day of taking 200mg of p5p. recovery. Pyridoxal-5-Phosphate (p5p) is the active form of B6, and pyridoxine hydrochloride, pyridoxal and pyridoxamine (different forms of B6 found in food) are converted in the liver to p5p. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Also I use Cialis, and more frequent injections like EOD or ED. Had morning wood waking up and have been super horny the past two days. I also take b complex along with it. B6 is metabolized to P5P by the liver. Or check it out in the app stores A Support subreddit for people with ADHD and anxiety Members Online. I would think Kava Kava and/or Ashwagandha and Maca and/or 5-HTP would be better. low dht can lead to low mood — symptoms like depression and mood swings have become associated with low DHT. There are some people in the group who have benefitted from creatine so hopefully they will comment. Reply reply Weekly-Note8149 Get the Reddit app Scan this QR code to download the app now. My dr recently had me try 25 mg of p5p yesterday am. We don't know how much. ) Reading about P5P Along with vitamin B12 and folate, vitamin B6 also helps break down homocysteine and thus protects your heart, brain, and reproductive health [3, 4, 5]. View community ranking In the Top 1% of largest communities on Reddit Is it possible that 3 weeks of taking B6 (P5P) has significantly decreased my anxiety? It also lowered my libido significantly and gave me erectile dysfunction which led to a couple years of performance anxiety. If you get anxiety and panic attacks from methylcobalamin, try taking 2-3 grams of glycine which should counteract it and calm you down. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. It’s tricky because I definitely think I have dopamine issues but at the same time I have anxiety issues. Lastly anything else worth using, and does P5P have a negative feedback loop when used for long duration? 100-200mg a day? So far, slight uptick in libido , and for sure uptick in erection quantity and quality of sensitivity. In the Top 1% of largest communities on Reddit. i tried 1000 iu of vit E for a few months and i dont think it helped much, maybe even gave me anxiety I have found that P5P (active vitamin b6) works wonders: brain fog is gone, sleep becomes way better, and my libido skyrockets. B6 half life is 25-33d. I took both. The b vitamins seem to be help with anxiety but I want to ask if it's good to take these supplements everyday without any issues. But eventually after a week or two, P5P causes me to become very fatigued and I start to get peripheral neuropathy. ME/CFS is a multi-systemic neurological disease, distinct from chronic fatigue as a symptom. This can form a buildup of pyridoxine HCl in the liver which becomes toxic. P5P 100mg severe anxiety and anger I Did a genetics test and it didnt show any MTHFR mutation, i dont react well to methylated B12, i take hydroxy b12 which doesnt give me any mental health issues. I felt fine until about 5 o clock pm and my anxiety started ramping up like horribly. So for high e2 the symptoms are as follows and they are in order of how they happen: bloat, oiliness, acne, performance anxiety, low libido and soft erection/minor ED. While taking it, it gave me more anxiety. Not a place for discussion of illicit and illegal compounds. Pyridoxal is probably safer, Pyridoxal is what's absorbed from P5P (pyridoxal-5'-phosphate. P5P isn't toxic B6 is. I was taking P5P because it was supposed to help with Sibo. Be really careful, I would stop supplementing if i were you. Open your eyes to the possibility that p5p is a fad and that p5p doesnt get absorbed as p5p and that it can cause toxcicity just as other forms of b6 can. nih. 5 hours, it’s also water soluble so you piss a lot of it out. P5P is necessary for the synthesis of nearly every neurotransmitter. if you have debilitatingly high prolactin, i dont think 50 or 100mg of p5p would lower it enough to get relief. never felt better than when on NPP recovery. Immediate cessation of fatigue. Maybe Adex would help you a lil too. It is always best to blood test levels first to see if you even need to supplement. Has anyone had problems with the other form of b6 and tried P5P and it worked for them? The other form gave me problems after a while. P5p made it like how I thought testosterone would go. vit E seems quite weak for this issue imo. wjzbi zttro ocmftjx emwureq cmzgu gbhinlgp yqkcybd yuium jpjyd lvhtzd wgioom fhbrck pmkoq wzhaw nffljgs